Advancing ‘transposon theory of aging’

A new study in the Proceedings of the National Academy of Sciences provides substantial new evidence that health becomes endangered when aging cells lose control of rogue elements of DNA called transposons. A new study increases and strengthens the links that have led scientists to propose the “transposon theory of aging.” Transposons are rogue elements of DNA that break free in aging cells and rewrite themselves elsewhere in the genome, potentially creating lifespan-shortening chaos in the genetic makeups of tissues. As cells get older, prior studies have shown, tightly wound heterochromatin wrapping that typically imprisons transposons becomes looser, allowing them…
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