Gene variants modifying Huntington’s symptom onset may lead to new therapeutic strategies

A study that took a novel approach to investigating factors affecting the emergence of symptoms of Huntington’s disease (HD) has identified at least two genome sites that house variants that can hasten or delay symptom onset. In their report in the July 30 issue of Cell, the multi-institutional research team describes how genome-wide association analysis of samples from more than 4,000 HD patients found that particular variants on two chromosomes were more common in individuals who first exhibited HD-associated movement disorders either earlier or later than would otherwise have been expected “Most previous research into ways of delaying the onset…
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