Lack of transcription factor FoxO1 triggers pulmonary hypertension

FoxO1 halts unrestrained cell division in pulmonary arteries. The images show photomicrographs of pulmonary arteries of rats with pulmonary hypertension. Whereas the blood vessel of an untreated rat is drastically reduced in diameter (left image), the vessel wall is essentially normalized after activation of FoxO1 (right).
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