New target identified to treat psoriasis

Sanford-Burnham scientists have identified the B and T Lymphocyte Attenuator (BTLA) inhibitory receptor as a key factor in limiting inflammatory responses, particularly in the skin. The study, published online today in Immunity, provides clarity on how T cells get fired up to protect against pathogens, and then cool down to restore immune homeostasis. “Our study shows that BTLA expression in gamma-delta T-cells deactivates their response to immune stimuli,” said Carl Ware, Ph.D., professor and director of the Infectious and Inflammatory Disease Center at Sanford-Burnham. “Gamma-delta T-cells are the first line of defense against pathogens – and unless ‘turned off’, can…
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