Cogan’s syndrome: An autoimmune inner ear disease

OBJECTIVES: The objective of our study was to review our current knowledge of the aetiopathogenesis of Cogan’s syndrome, including viral infection and autoimmunity, and to discuss disease pathogenesis with relevance to pharmacotherapy. SYSTEMATIC REVIEW METHODOLOGY: Relevant publications on the aetiopathogenesis and pharmacotherapy of Cogan’s syndrome from 1945 to 2012 were analysed. RESULTS AND CONCLUSIONS: Cogan’s syndrome is a rare autoimmune vasculitis, and its pathogenesis is unknown. Infection, but primarily autoimmunity, may play contributing roles in the pathogenesis of this disease. It is characterised by ocular and audiovestibular symptoms similar to those of Meniere’s syndrome. Approximately 70% of patients have systemic…
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